Recent Lab Publications
Boulton DP, Caino MC. “Emerging roles for Mitochondrial Rho GTPases in tumor biology”. J Biol Chemistry
, September 2024; 300:9. https://doi.org/10.1016/j.jbc.2024.107670.
In this review, we summarize evidence that MIRO1 and MIRO2 are important regulators of tumor cell biology.
Boulton DP, Caino MC. “Mitochondrial Fission and Fusion in Tumor Progression to Metastasis”. Front. Cell Dev. Biol., 09 March 2022 | https://doi.org/10.3389/fcell.2022.849962.
In this review, we discuss emerging evidence linking mitochondrial fragmentation with tumor progression to metastasis.
-AACR Editor’s pick-
Furnish M; Boulton DP; Genther V; Grofova D; Ellinwood ML; Romero L; Lucia MS; Cramer SD; Caino MC. “MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling”. Mol Cancer Res 2022 Apr 1;20(4):607-621. doi: 10.1158/1541-7786.MCR-21-0374.
In this manuscript, we identify a novel crosstalk between mitochondria and the integrated stress response in prostate cancer.
-Top cited article from Cancer Reports-
Furnish M, Caino MC. “Altered mitochondrial trafficking as a novel mechanism of cancer metastasis”.Cancer Rep (Hoboken)
. 2020 Feb;3(1):e1157. doi: 10.1002/cnr2.1157.
In this review, we discuss emerging evidence that implicates exacerbated mitochondrial movement as a contributor to metastatic potential of cancer cells.
Other recent publications from the Lab
Williams M, Caino MC. “Mitochondrial Dynamics in Type 2 Diabetes and Cancer”. Front Endocrinol. 2018 Apr 27;9:211. doi: 10.3389/fendo.2018.00211. eCollection 2018. Review. PMID: 29755415. PMCID: PMC5934432.
Caino MC, Seo JH, Wang Y, Rivadeneira DB, Gabrilovich DI, Kim ET, Weeraratna AT, Languino LR, Altieri DC. “Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer”. J Clin Invest. 2017 Sep 11. pii: 93172. doi: 10.1172/JCI93172. PMID: 28891816. PMCID: PMC5617650.
Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC. “A neuronal network of mitochondrial dynamics regulates metastasis”. Nat Commun 2016 7, 13730 doi: 10.1038/ncomms13730. PMID: 27991488. PMCID: PMC5187409.
Caino MC and Altieri DC. “Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy”. Clin Cancer Res. 2016 Feb 1;22(3):540-5. doi: 10.1158/1078-0432.CCR-15-0460. PMID: 26660517. PMCID: PMC4738153.
Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. et al. “PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion”. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8638-43. PMID: 26124089. PMCID: PMC4507184.
Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O’Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC. “Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells”. J Clin Invest. 2013 Jul;123(7):2907-20. PMID:23921130. PMCID: PMC3998961.
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